GLUT4 - an overview ScienceDirect Topic

  1. GLUT4 in muscle and adipose tissue is indispensable for glucose homeostasis. 349 Specific deletion of GLUT4 from muscle or adipocytes dysregulates glucose homeostasis and promotes insulin resistance to a much greater extent than deletion of insulin-signaling components from these tissues alone. 350 Muscle-specific GLUT4-knockout (MG4KO) mice develop hyperglycemia, glucose intolerance, and.
  2. GLUT4 is one of 13 sugar transporter proteins (GLUT1-GLUT12, and HMIT) encoded in the human genome (Joost and Thorens, 2001, Wood and Trayhurn, 2003) that catalyzes hexose transport across cell membranes through an ATP-independent, facilitative diffusion mechanism (Hruz and Mueckler, 2001).These sugar transporters display differences in their kinetics and respective substrate specificities.
  3. GLUT4 is a glucose transport protein found in fat and striated muscle cells. In a person with normal metabolism, insulin is secreted from the pancreas after eating. Insulin signals fat and muscle cells to absorb glucose from the blood by binding to the insulin receptor on the surface of fat and muscle cells
  4. The principal glucose transporter protein that mediates this uptake is GLUT4, which plays a key role in regulating whole body glucose homeostasis. This review focuses on recent advances on the biology of GLUT4. Publication types Research Support, N.I.H., Extramural.
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  6. fra Wikipedia, den frie encyklopedi. SLC2A4; identifikatorer; aliaser: SLC2A4, GLUT4, oppløst bærerfamilie 2 medlem 4: Eksterne ID-er: OMIM: 138190 MGI: 95758.
  7. Glucose is an important fuel for contracting muscle, and normal glucose metabolism is vital for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4 glucose transporter which translocates from intracellular storage depots to the plasma membrane and T-tubules upon muscle

The GLUT4 Glucose Transporter - ScienceDirec

  1. GLUT4 levels in human skeletal muscle fiber types before and after short-term, low-intensity exercise training. Note that differences in GLUT4 content between the different fiber types are relatively small compared with findings in rodents
  2. GLUT4 content and glucose transport during intense elec-trical stimulation of rat skeletal muscles (116) and the rela-tionship between GLUT4 expression and insulin action in skeletal muscle. In this regard, increased skeletal muscle GLUT4 expression would also facilitate postexercise glu-cose uptake and glycogen storage (100, 198)
  3. GLUT4 is highly expressed in adipose tissue and skeletal muscle, but these tissues also express a selective cohort of these other transporters. In the case of skeletal muscle, GLUT1, GLUT5, and GLUT12 may significantly contribute to sugar uptake in addition to GLUT4 (Stuart et al., 2000. Stuart C.A
  4. Glut4 plasma membrane translocation and glucose uptake are induced by insulin and leptin in a human neuronal cell line by a phosphatidylinositol 3-kinase- dependent mechanism; enhanced GLUT4 activity was paralleled by increased transporter abundance in the plasma membrane

Glut4: Products. Facilitative simple sugar uptake by mammalian cells is mediated by a family of glucose transporters. Gluts are predicted to contain 12 transmembrane domains with both amino- and carboxyl-termini located within the cytosol Intracellular Glut4 also co-localizes with LRP1 (low density lipoprotein receptor-related protein 1), the receptor for α 2-macroglobulin (α 2-M) expressed in adipocytes. Like Glut4, there are two kinetically distinct pools of LRP1 in adipocytes, a rapidly cycling pool, and a slowly cycling/non-cycling pool DEFINITION . GLUT4 is one of 13 sugar transporter proteins (GLUT1- GLUT12, and HMIT) encoded in the human genome that catalyzes hexose transport across cell membranes through an ATP-independent, facilitative diffusion mechanism. GLUT4 is highly espresse in adipose tissue and skeletal muscle.It displays the unique characteristic of a mostly intracellular disposition in the unstimulated state.

GLUT4_HUMAN Accession i: P14672 Primary (citable) accession number: P14672 Secondary accession number(s): Q05BQ3, Q14CX2: Entry history i: Integrated into UniProtKB/Swiss-Prot: April 1, 1990: Last sequence update: April 1, 1990: Last modified: August 12, 2020: This is version 225 of. Anti-Glucose Transporter GLUT4 antibody (ab33780) at 1 µg/ml + Partial tagged recombinant protein to GLUT4 at 0.1 µg Secondary IRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilution Predicted band size: 55 kDa Observed band size: 30 kD In mammals that do produce Vitamin C, GLUT4 is often expressed instead of GLUT1. Tissue distribution. GLUT1 expression occurs in almost all tissues, with the degree of expression typically correlating with the rate of cellular glucose metabolism ulation of GLUT4 translocation have been identified (BOX 2),any convergence between these two approaches remains to be achieved.In this review, we focus on our cell-biological understanding of GLUT4 transport, and highlight potential regulatory sites of the insulin-signalling cascade. GLUT4 transport GLUT4 is found in many organelles, including th Glut4 Antibody (IF8) is a high quality monoclonal Glut4 antibody (also designated Glucose transporter type 4 antibody, GLUT-4 antibody, or SLC2A4 antibody) suitable for the detection of the Glut4 protein of mouse, rat and human origin

GLUT4 Antibodies . This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin,. GLUT4 could be retained in either a static or a dynamic pool . The static model proposes that GLUT4 may be retained intracellularly by an interaction between GSVs and retention machinery such as TUG (tether, containing a UBX domain, for GLUT4) , p115. Where Is GLUT4? This has been one of the major questions capturing the imagination of GLUT4 biologists. Early electron microscopy studies were perhaps the most informative showing an enrichment of GLUT4 in tubulo-vesicular elements scattered throughout the cytoplasm of the adipocyte or enriched near t-tubules in muscle with an additional localization in endosomes and the trans-Golgi network.

Looking for online definition of GLUT4 or what GLUT4 stands for? GLUT4 is listed in the World's largest and most authoritative dictionary database of abbreviations and acronyms The Free Dictionar

GLUT4 (acrónimo (en inglés) glucose transporter type 4) es una proteína transportadora de glucosa regulada por la insulina, que se localiza en los adipocitos, el músculo esquelético y el miocardio. [1]. The insulin-independent increase in GLUT4-dependent muscle glucose use indicates that an alternative intracellular signaling pathway must be activated to stimulate GLUT4 translocation to the plasma membrane. AMPK appears to play an essential role in stimulating GLUT4 translocation during contraction or hypoxia (16, 20, 27)

What is GLUT4? (with pictures) - wiseGEE

Glut4 products available through Novus Biologicals. Browse our Glut4 product catalog backed by our Guarantee+ GLUT4, one of the most studied members of the GLUT family of glucose transporters, plays the central role in maintaining glucose homeostasis at cellular and physiological levels. Insulin induces GLUT4 translocation from intracellular storage vesicles to the cell surface where it drives postprandial glucose uptake and maintenance of euglycemia A Large Proportion of the Cell Surface GLUT4 Is Found in Caveolae from 3T3-L1 Adipocytes or Isolated Rat Adipocytes. Rotatory replicas of plasma membrane lawns from 3T3-L1 adipocytes contained cytoskeletal elements, clathrin lattices, pits, and caveolae, sometimes organized in bunches (Fig. 1).Unstimulated adipocytes showed only 2.9 gold particles of labeled GLUT4 per μm 2 in plasma membrane. References ↑ Huang S, Czech MP. The GLUT4 glucose transporter. Cell Metab. 2007 Apr;5(4):237-52. PMID:17403369 doi:http://dx.doi.org/10.1016/j.cmet.2007.03.006. Exercise increases GLUT4 translocation to the sarcolemma and t-tubule and, over the longer term, total GLUT4 protein content. Here, we review key aspects of GLUT4 biology in relation to exercise, with a focus on exercise-induced GLUT4 translocation, postexercise metabolism and muscle insulin sensitivity, and exercise effects on GLUT4 expression

glut4 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә. Искәрмәлә GLUT4 is an insulin-regulated glucose transporter that is responsible for insulin-regulated glucose uptake into fat and muscle cells. In the absence of insulin, GLUT4 is mainly found in intracellular vesicles referred to as GLUT4 storage vesicles (GSVs). Here, we summarise evidence for the existence of these specific vesicles, how they are sequestered inside the cell and how they undergo. GLUT4, one of the isoforms of GLUT, is found in adipose and skeletal tissues. It transports 6-membered sugars into the cell in an ATP dependent manner. As shown by W. W. Winder et al, during times of exercise, the concentration of GLUT4 increases tremendously in order to accommodate the energy requirements of the cell.(7

The GLUT4 glucose transporter - PubMe

  1. SLC2A4: A gene on chromosome 17p13 that encodes insulin-responsive glucose transporter type 4, a plasma membrane that mediates facilitated glucose transport. Molecular pathology SLC2A4 mutations are associated with type-2 (non-insulin-dependent) diabetes
  2. Metabolic syndrome is characterized by insulin resistance, which is closely related to GLUT4 content in insulin-sensitive tissues. Thus, we evaluated the GLUT4 expression, insulin resistance and inflammation, characteristics of the metabolic syndrome, in an experimental model. Spontaneously hypertensive neonate rats (18/group) were treated with monosodium glutamate (MetS) during 9 days, and.
  3. Glut4 is a 12-transmembrane domain protein that facilitates glucose transport in the direction of the glucose gradient. This transporter localizes to intracellular organelles (endosomes) in unstimulated cells and translocates to the cell surface following insulin stimulation (1,2,4)
  4. GLUT4 translocates from an ill-defined intracellular compartment to the plasma membrane in response to insulin. The total cellular content of GLUT4 is significantly decreased in adipose cells from many patients with Type II diabetes mellitus, and animals with some types of experimental diabetes

Approximately 70% of women with polycystic ovary syndrome (PCOS) have intrinsic insulin resistance (IR) above and beyond that associated with body mass, including dysfunctional glucose metabolism in adipose tissue (AT). In AT, analysis of the IRS/PI3-K/AKT pathway signaling components identified only GLUT4 expression to be significantly lower in PCOS patients and in control subjects with IR Anti-Glucose Transporter GLUT4 antibody [mAbcam48547] - BSA and Azide free (ab238661) Description: Mouse monoclonal [mAbcam48547] to Glucose Transporter GLUT4 - BSA and Azide fre Products linked with gene. Glut4 Antibody. Catalog number: E-AB-30268-2 The GLUT4 facilitative glucose transporter mediates insulin-dependent glucose uptake. We tested the hypothesis that moderate overexpression of human GLUT4 in mice, under the regulation of the human GLUT4 promoter, can prevent the hyperinsulinemia that results from obesity. Transgenic mice engineered to express the human GLUT4 gene and promoter (hGLUT4 TG) and their nontransgenic counterparts.

Physiology, Glucose Transporter Type 4 Articl

  1. Richter, EA & Hargreaves, M 2013, ' Exercise, GLUT4, and skeletal muscle glucose uptake ', Physiological Reviews, bind 93, nr. 3, s. 993-1017. https://doi.org/10.1152.
  2. GLUT4 is in the family of solute carriers and is responsible for facilitating the transport glucose into the cells in response to insulin [3]. For this reason, mutations in GLUT4 have been associated with Type 2 diabetes [4]. The GLUT4 gene has been mapped to the region 13 in the short arm of chromosome 17 (17p13) [5]
  3. ed in GLUT4 null mice and in murine models of dilated and hypertrophic cardiomyopathy. GLUT4, GLUT1, and GLUT8 were found to be the most abundant GLUT transcripts in the normal heart, while GLUT3, GLUT10, and GLUT12 are present at relatively lower levels
GLUT4 - Proteopedia, life in 3D

GLUT4 has a half-life of 50 h in the absence of insulin in murine adipocytes [20], thus GLUT4 sorting mechanisms appear to be efficient, preventing either mistargeting of GLUT4 to the cell surface when not required, or mis-sorting to degradative compartments Invitrogen Anti-GLUT4 Monoclonal (1F8), Catalog # MA1-83191. Tested in Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen) (IHC (F)), Immunohistochemistry (Paraffin) (IHC (P)) and Immunoprecipitation (IP) applications. This antibody reacts with Human, Mouse, Non-human primate, Porcine, Rabbit, Rat samples. Supplied as 50 µg purified antibody (1 mg/mL)

Neuronal LRP1 Regulates Glucose Metabolism and Insulin

GLUT4 - GLUT4 - qwe

  1. Our Glut4 Antibodies can be used in a variety of model species: Human, Monkey, Mouse, Porcine, Rabbit, Rat. Use the list below to choose the Glut4 Antibody which is most appropriate for your research; you can click on each one to view full technical details, images, references, reviews and related products
  2. GLUT4 sees this as a signal to begin transporting glucose into the skeletal muscles, acting as some sort of gatekeeper. How to Benefit from Them. Surely, AMPK and GLUT4 are capable of providing you with several important perks - and that means you'll have to find ways to stimulate their production or induce their respective reactions
  3. Conditional depletion of GLUT4 in either adipose tissue or skeletal muscle causes insulin resistance and a roughly equivalent incidence of diabetic animals (Zisman et al., 2000 and Abel et al., 2001)
  4. Erythrocyte Glut4 protein levels were significantly increased in anemic mice, with an augmentation of 6-fold by day 6 following induction of anemia. Moreover, Glut4 levels were higher in the PHZ-treated animals compared with the phlebotomized mice, with the former displaying a much more severe anemia (Figure 4A; data not shown)
  5. The insulin-regulated glucose transporter-4 (GluT4) is critical for insulin- and contractile-mediated glucose uptake in skeletal muscle. GluT4 is also expressed in some hippocampal neurons, but its functional role in the brain is unclear. Several established molecular modulators of memory processing regulate hippocampal GluT4 trafficking and hippocampal memory formation is limited by both.

Exercise, GLUT4, and skeletal muscle glucose uptak

Exercise, GLUT4, and Skeletal Muscle Glucose Uptake

A decade has passed since the cloning of the insulin-responsive glucose transporter, GLUT4.Numerous studies have demonstrated the complex hormonal and metabolic regulation of GLUT4 gene expression in adipose tissue and muscle. Careful dissection of the regulatory elements in the GLUT4promoter has provided insight into the intricate control of this central gene of glucose homeostasis GLUT4 Antibody is available 2 times from Biovision labs 3945-30T | GLUT4 Antibody size: 2X30 µg | 386.88 USD 3945-200 | GLUT4 Antibody size: 200. GLUT4 particles were counted in five squares from unstimulated cells, ruffled areas in insulin-treated cells or nonruffled areas in insulin-treated cells. Image J, a public-domain Java image-processing program inspired by NIH Image software, was used to analyze the grids. SPSS software (version 10; SPSS Inc.,.

rx_of_diabetes [TUSOM | Pharmwiki]

The GLUT4 translocation process is complex, but can be dissected into at least four discrete trafficking steps. This raises the question as to which of these is the major regulated step in insulin‐stimulated GLUT4 translocation. Numerous molecules have been reported to regulate GLUT4 trafficking GLUT4. 29 likes. Glucose transporter type 4, also known as solute carrier family 2, facilitated glucose transporter member 4, is a protein encoded, in.. Anti-GLUT4 Antibody from Alomone Labs is a highly specific rabbit polyclonal Ab directed against an epitope of the human glucose transporter 4. Applications: IHC, WB. Free samples available. Control antigen included. Lyophilized. Global shipping at room temperature. Your top supplier for glucose transporter research Imaging GLUT4 translocation to the plasma membrane: Insulin stimulates glucose uptake by promoting the translocation of the GLUT4 isoform of glucose transporter to the plasma membrane. We have been able to follow GLUT4 movements in living cells using time-lapse confocal microscopy GLUT4_RAT Accession i: P19357 Primary (citable) accession number: P19357 Secondary accession number(s): P97900: Entry history i: Integrated into UniProtKB/Swiss-Prot: November 1, 1990: Last sequence update: November 1, 1990: Last modified: October 7, 2020: This is version 188 of.

Glucose Transporters and Insulin Action — Implications forExercise-dependent glucose uptake in skeletal muscleA Critically Swift Response: Insulin-Stimulated Potassium

Exercise, GLUT4, and Skeletal Muscle Glucose Uptak

medicinepainneuropathy lifestyle changes. There are many experienced and best diabetologists who customise the treatments by analysing the health condition of every individual, along with genetic testing as and when required Glut4 Videos; Playlists; Channels; Discussion; About; Home Trending History Get YouTube Premium Get YouTube TV Best of YouTube Music Sports Gaming. GLUT4, glucose transporter 4 PAK, P21‐activated kinase Rac1, Rat Ras‐related C3 botulinum toxin substrate 1 Skeletal muscle is the primary tissue of glucose metabolism, accounting for up to 80% of dietary glucose uptake Defective translocation of glucose transporter 4 (GLUT4) to the cell surface is a key feature of insulin resistance in type 2 diabetes. Therefore, elucidating the mechanism of GLUT4 translocation is of primary importance. The mammalian Bag6/Bat3 gene has been suggested to be linked with potential obesity- and diabetes-associated loci, while its function in the control of glucose incorporation. Exercise increases glucose uptake and the use in skeletal muscles by increased translocation and expression of glucose transporter 4 (GLUT4, an isoform of glucose transporter) from intracellular storage depots to plasma membrane, and by increasing insulin sensitivity. 34-36 Exercise also improves hepatic insulin sensitivity, reduces insulin.

Staphylococcus aureus blocks insulin function | NatureMatthew Brown Horse obesity %article_desc% How horse

The GLUT4 Glucose Transporter: Cell Metabolis

For GLUT4 translocation analysis (C), cultivated cells were insulin stimulated (+) for 20 min or not (−). Immunofluorescence shows GLUT4 (red), nuclear marker DAPI (blue) and plasma membrane marker WGA (green). Merged images show the plasma membrane GLUT4 localization (yellow). Images are representative of at least 3 independent experiments Abstract. Individual amino acids, amino acid mixtures and protein hydrolysates stimulate glucose uptake in many experimental models. To replicate better in vitro the dynamic postprandial response to feeding in vivo, in the present study we investigated the effects of culture media conditioned with fasted and postprandial human serum on GLUT4 translocation in L6‐GLUT4myc myotubes Insulin-stimulated glucose transport is impaired in a genetic model of hypertension, the stroke-prone spontaneously hypertensive rat (SHRSP), yet the molecular mechanisms that underlie this defect in the animals remain unclear. We examined the effects of insulin on the trafficking of the insulin-responsive glucose transporter GLUT4 to the plasma membrane in isolated adipocytes from SHRSP and. RESEARCH Open Access Palmitoleic acid (n-7) increases white adipocytes GLUT4 content and glucose uptake in association with AMPK activation Andressa Bolsoni-Lopes1, William T Festuccia1, Patricia Chimin1, Talita SM Farias1, Francisco L Torres-Leal1, Maysa M Cruz2, Paula B Andrade3, Sandro M Hirabara3, Fabio B Lima1 and Maria Isabel C Alonso-Vale2* Abstrac Interestingly, the clear increase in surface‐exposed GLUT4 content induced by insulin, exercise or AMPK activation was not accompanied by any discernible reorganization of the GLUT4‐GFP signal. In conclusion, we provide a detailed description of an easy‐to‐use translocation assay to study GLUT4 accumulation at the surface membrane induced by exercise and exercise‐mimicking stimuli

G Protein–Coupled Receptor Kinase 2 | Circulation Research

6517 - Gene ResultSLC2A4 solute carrier family 2 member 4

GLUT4-deficient mice develop striking cardiac hypertrophy and die prematurely, but it was unclear whether their cardiac changes were caused primarily by GLUT4 deficiency in cardiomyocytes or by metabolic changes resulting from the absence of GLUT4 in skeletal muscle and adipose tissue ofneuropathysymptoms This remarkable botanical for blood sugar control has been clinically shown to treat mild and moderate type 2 diabetes. It is a traditionally used.

Glut4 Products: R&D System

Glut4 (Glucose Transporter Member 4), also known as SLC2A4, is a 509 aa multi-pass type membrane protein and shares 65% aa identity with mouse Glut4. It is an insulin-regulated glucose transporter. Glut4 is most highly expressed in adipose and striated muscle tissues, but has also been reported in multiple other tissues including the nervous system and breast cancer Glucose transporter 4 (GLUT4) is involved in regulating glucose uptake in striated muscle, liver, and adipose tissue. Neferine is a dibenzyl isoquinoline alkaloid derived from dietary lotus seeds and has multiple pharmacological effects. Therefore, this study investigated neferine's role in glucose translocation to cell surface, glucose uptake, and GLUT4 expression Biogenesis Inc glut4 Glut4, supplied by Biogenesis Inc, used in various techniques. Bioz Stars score: 92/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and mor Question: The Plasma Membrane Localization Of GLUT4 Is Regulated By Insulin. High Blood Glucose Levels, Following The Consumption Of A Meal, Triggers Production And Secretion Of Insulin Into The Blood Stream. In Muscle, Adipose And Liver Cells, Insulin Binds To The Insulin Receptor (IR) To Stimulate A Signaling Pathway That Leads To Fusion Of GLUT4 Containing.

Insulin-regulated Glut4 Translocatio

glut4 モノクローナル抗体(品番:66846-1-ig) 図1 Various lysates were subjected to SDS PAGE followed by western blot with 66846-1-Ig (GLUT4 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hour Hypothalamic GLUT4 mRNA abundance increases with age and is sexually dimorphic.but decression in hippocampus and amygalda. PMID: 24382486; Ca(2+)-induced glut4 transporter translocation might be crucial under excessive cardiac stress conditions that require supraphysiological energy demands. PMID: 2489528 GLUT4 plays an important role in the metabolic homeostasis by regulation of glucose uptake in insulin-sensitive tissues, such as adipose and muscle. 26,27) In response to insulin signal, GLUT4 translocates to the PM from cytoplasm via a signal cascade involving various molecules such as IRS-1 and AKT. 28-30) As a result, extracellular glucose uptake is increased and blood glucose levels are. songtiksugar janumet. It's totally normal to have one testicle that's larger than the other. Sudden changes in testicle size that are accompanied by other symptoms like1 hour) and lasts for 2 hours.The test is preceded by venesection before the glucose load and followed by a second venesection 2 hours after the consumption of a drink containing 75 g of glucose

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